Principal Investigator
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Meng-chun Ye

mcye@nankai.edu.cn

Tel: 022-2350-4701

●B.S.,Lanzhou University (2001);

● Ph.D.,Shanghai Institute of Organic Chemistry, CAS (2006);

●Postdoc, University of North Carolina at Chapel Hill, USA (2006-2009);

●Research Associate, The Scripps Research Institute, USA (2009-2013);

●Nankai University Hundred Young Academic Leaders Program (2014);

*Research Interests: Organic Synthesis, Organometallic Chemistry, and Chemical Biology


1. Yu-Xin Luan, Tao Zhang, Wei-Wei Yao, Ke Lu, Lu-Yao Kong, Yu-Tong Lin, and Mengchun Ye*. Amide-Ligand-Controlled Highlypara-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids. J. Am. Chem. Soc.,2017, 139 (5), pp 1786–1789

2. Jin-Fei Yang, Rong-Hua Wang, Yin-Xia Wang, Wei-Wei Yao, Qi-Sheng Liu, Mengchun Ye*. Ligand-Accelerated DirectArylation of BINOL: A Rapid One-Step Synthesis of Racemic 3,3’-Diaryl BINOLs. Angew. Chem. Int. Ed. 2016, 55, 14116-14120.

3. Yan-Long Zheng, Yu-Xin Luan, Mengchun Ye*. Recent Progress in Base Metal Catalyzed (Transfer) HydrogenativeCouplings of Carbonyls with π-Unsaturated Compounds. Synlett. 2016, 27,2401-2406 (Invited Review).

4. Yan-Long Zheng, Yan-Yao Liu, Yi-Mei Wu, Yin-Xia Wang, Yu-TongLin, Mengchun Ye*. Iron Catalyzed   Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes. Angew. Chem. Int. Ed. 2016, 55, 6315-6318.

5. A Robust Protocolfor Pd(II)-catalyzed C-3 Arylation of (1H) Indazoles and Pyrazoles:Total Synthesis of Nigellidine Hydrobromide. Mengchun Ye, Andrew J. F. Edmunds, James A. Morris, David Sale, YejiaZhang, and Jin-Quan Yu.Chem. Sci. 2013, 4, 2374.

6. Ligand-Promoted C-3-Selective Arylation of Pyridines with Pd Catalysts: Gram-Scale Synthesis of(±) Preclamol. Mengchun Ye,Guo-Lin Gao, Andrew J. F. Edmunds, P. A. Worthington, James A. Morris, Jin-Quan Yu J.Am. Chem. Soc.2011, 133,19090.

7. Ligand-Promoted C-3Selective C–H Olefinationof Pyridines with Pd Catalysts.Mengchun Ye,Guo-LinGao, Jin-Quan Yu J. Am. Chem.Soc. 2011,133, 6964.

8.Trisoxazoline/Cu(II)-promoted Kinugasa Reaction. Enantioselective Synthesis of β-Lactams.Meng-Chun Ye, Jian Zhou, andYong Tang J. Org. Chem. 2006, 71, 3576.

9. DiastereoselcetiveTandem Michael Additions of Indoles to 3-Nitrocoumarin Derivatives and Methyl Vinyl Ketone.Meng-Chun Ye, Yao-Yu Yang, Yong Tang, Xiu-Li Sun, Zhi Ma, and Wei-Min Qin Synlett, 2006, 1240.

10. Modular Synthesisof Chiral Homo- and Heterotrisoxazolines. Improving the Enantioselectivity inthe Asymmetric Michael Addition of Indole to BenzylideneMalonate.Meng-Chun Ye,Bin Li, Jian Zhou, Xiu-Li Sun, and Yong Tang J.Org. Chem. 2005, 70, 6108.

11. ChiralTris (oxazoline)/Cu(II) Catalyzed Coupling of Terminal Alkynes andNitrones. Meng-Chun Ye, Jian Zhou, Zheng-Zheng Huang, and Yong Tang Chem. Commun. 2003, 2554.

12. Pd(II)-Catalyzed Phosphorylation of Aryl C–H Bonds.Chen-Guo Feng, Mengchun Ye, Kai-Jiong Xiao,Suhua Li, and Jin-Quan Yu J. Am. Chem. Soc.2013, 135, 9322.

13. Structural Insightinto the Substrate Specificity of Phosphodiesterases.HengmingKe, Huanchen Wang, Mengchun Ye Handbook of Experimental Pharmacology 2011, 204, 121.

14. Insight intoBinding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures andMutagenesis.Huanchen Wang, Xuan Luo, Mengchun Ye, Jin Hou, Howard Robinson,HengmingKe J. Med. Chem.2010 53,1726.

15.Trisoxazoline/Cu(II)-catalyzed asymmetric intramolecular Friedel-Craftsalkylation reaction of indoles.Jiao-Long Zhou, Meng-Chun Ye, Xiu-Li, Sun, YongTang Tetrahedron 2009, 65, 6877.

16. Conformation alvariations of both PDE5 and inhibitors provide the structural basis for thephysiological effects of vardenafil and sildenafil.Huanchen Wang, Mengchun Ye, Howard Robinson, Sharron H Francis, Hengming Ke MolPharmacol 2008, 73, 104.

17. Pyrrolidine-thioureaas a bifunctionalorganocatalyst: highly enantioselective Michael additionofcyclohexanone to nitroolefins.Chun-Li Cao, Meng-Chun Ye,Xiu-Li Sun, and YongTang Org. Lett.2006, 8, 2901.

18. Sidearm approach: APromising Strategy for Rapid Construction of Bisoxazoline-Based LigandLibrary.Jian Zhou, Meng-Chun Ye, and Yong Tang J. Comb. Chem. 2004, 6, 301.

19. Controllable Enantioselective Friedel-Crafts Reaction between Indoles and Alkylidene   Malonates Catalyzed by Pseudo-C3-Symmetric Trisoxazoline Copper(II) Complexes. Jian Zhou,Meng-Chun Ye, Zheng-Zheng Huang, and Yong Tang J. Org. Chem. 2004, 69, 1309.

20.Diastereoselectivity-Switchable and Highly Enantioselective 1, 3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates.Zheng-Zheng Huang, Yan-BiaoKang, Jian Zhou, Meng-Chun Ye and Yong Tang Org.Lett.2004, 6, 1677.

21. A New Xanthanolide from Carpesiumlongifolium.Chao Yang, Meng-Chun Ye, Zhong-Jian Jia Chin. Chem.Lett. 2003, 14, 483.